The Pre-Clinical Studies of Naringin,An Innovative Drug,Derived from Citri Grandis Exocarpium（ Huajuhong）Chinese Full Text
LI Peibo;WANG Yonggang;WU Zhong;PENG Wei;YANG Cuiping;NIE Yichu;LIU Menghua;LUO Yulong;ZOU Wei;LIU Yin;WANG Sheng;CHEN Yan;SU Chang;FANG Siqi;SU Weiwei;School of Life Sciences,Sun Yat-sen University;
Abstract: Naringin is a pharmacologically active compound extracted and purified from Citri Grandis Exocarpium（ Huajuhong）. During the past more than ten years,naringin has been developed into a classⅠinnovative drug to treat cough by our group. The Drug Clinical Trial Approval of naringin was issued by China Food and Drug Administration. As such,this review aims to summarize all of pre-clinical studies of naringin from our laboratory,including pharmacological effects and acting mechanisms,non-clinical pharmacokinetics and toxicological evaluation.
Keywords：
class Ⅰ new drug; naringin; pre-clinical research; pharmacological effect; pharmacokinetics; toxicology;
- DOI：
10.13471/j.cnki.acta.snus.2015.06.001
- Series：
- Subject：
- Classification Code：
R284;R285
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