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Diversity and bioactivity of cultured aquatic fungi from the High Arctic region

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【作者】 ZHANG TaoZHAO LiliYU CaiyunWEI TaoYU Liyan

【Author】 ZHANG Tao;ZHAO Lili;YU Caiyun;WEI Tao;YU Liyan;China Pharmaceutical Culture Collection,Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences& Peking Union Medical College;Beijing Key Laboratory of Bioactive Substances and Function Food,Beijing Union University;

【机构】 China Pharmaceutical Culture Collection,Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences& Peking Union Medical CollegeBeijing Key Laboratory of Bioactive Substances and Function Food,Beijing Union University

【摘要】 This study assessed the diversity and α-glycosidase inhibitory activity of cultured fungi isolated from four aquatic environments(stream, pond, glacial ice, and estuary) in the Ny-?lesund region(Svalbard, Norway, High Arctic). A total of 134 fungal isolates were obtained from 13 water samples. Based on morphological characteristics and sequence analyses of the nuclear ribosomal DNA internal transcribed spacer region, these fungal isolates were identified as belonging to 47 species, with 26 belonging to the Ascomycota, 20 to the Basidiomycota, and one to the Zygomycota. The most frequently detected fungal species were Vishniacozyma sp. 2, Cadophora sp. 2, Phenoliferia sp. 1, Dioszegia sp. 2, and Mortierella sp.; these species occurred in 10, eight, seven, six, and five of the samples, respectively. Among the 134 fungal isolates, 17 isolates of 15 species displayed high α-glycosidase inhibitory activity in culture. The results suggest that diverse and distinct populations of cultured fungi are present in Arctic aquatic environments, and they include taxa that are potential sources of bioactive molecules that may be used as prototype drugs for medicinal proposals.

【基金】 supported by the National Natural Science Foundation of China (NSFC) (Grant nos.31670025 and 31300115);Projects of the Chinese Arctic and Antarctic Administration,State Oceanic Administration (Grant no.2013YR06006);the National Infrastructure of Microbial Resources (Grant no.NIMR-2017-3);the CAMS Innovation Fund for Medical Sciences (Grant no.2016-I2M-2-002)
【所属期刊栏目】 Article (2017年01期)
  • 【DOI】10.13679/j.advps.2017.1.00029
  • 【分类号】Q93
  • 【下载频次】5
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