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A Randomized Study of Chemotherapy and Traditional Medicine in Hematology Malignancy:Report of Twenty-five Cases

George Zhu1Sarah E.Mische2Beatrice.Seigneres3

1. The Institute of oncology of George Zhu2. Medtronic,Inc.Ventures & New Therapies,Minneapolis,Minnesota,USA3. R & D IA biomerieux,Marcy I' Etoile,France

摘要:<正>Traditional systems of medicine all over the world even traditional medicine and cancer have been using plants and plants products for therapeutic purposes.In my group,25 patients with hematologic malignancy and other available cancers were entered in the study during 1993-2011.The complete remission(CR) was obtained in 23 of 25 hematology malignancy and advanced cancers.During follow up,the survival time in three lung cancer was 5,10 and 17 years,l jaundice cholangiocarcinoma was near 2 years,l gallbladder cancer 10 years,9 lymphoma over 10-20 years,1 gastric cancer 7 years,1 thyroid cancer 5 years,1 refractory anemia over 7 years,1 multiple myeloma 3 years.and 2 chronic granulocytic leukemia(CGL) 5 years and 8 years respectively.CR was once obtained after all-trans retinoic acid(RA) and 1 mg homoharringtonine intravenously in one case of acute promyelocytic leukemia(APL).A CR was achieved by use of chlorambucil and traditional medicine in 1 chronic lymphocytic leukemia with his peripheral leukocytes 123.88x10~9/1,with a leukocyte differential count of 85%small lymphocytes.In this study,I experienced that a CR was a pivotal influencing factor in those longest survival patients,and traditional medicine was also recommended. As a novel approach to APL treatment,one possible the action of RA,A consense sequence(5’- TCAGGTCATGACCTGA-3’) has been postulated for the thyroid hormone(TRE) and retinoic acid responsive element(RARE) containing half palindromes,which located in the promoter region of target genes.High dose(100-fold) of RA-RARE- PML/RARa complex in intracellular localization appears to relieve repressor from DNA binding,including corepressors N-CoR,SMRT and HDAcs, release PML/RARa- mediated transcriptional repression,and release histone deacetylase activity from PML-RARa.The resulting PML/RARa oncoprotein proteolytic degradation through the autophagy-lysosome pathway and the ubiquitin SUMO-proteasome system(UPS),as well as caspase 3(cleavage site Asp522 within a-helics region of PML component of the fusion protein)or neutrophil elastase,or lysosomal protease enzyme induction.An effect to relieve the blockade(inhibition) of PML/RARA-mediated RA dependent promyelocytic differentiation,and all-trans retinoic acid in APL therapy.Here,like v-erbA,PML/RARa is a(strong) transcriptional repressor of the RA receptor(RAR) complex,and PML/RARa fusion receptor gene act as conditional oncogenic receptor(translocated chimeric retinoic acid receptor a signaling) or oncogenic PML/RARa may participate in leukem ogenesis of APL through blocking RAmediated promyelocytic differentiation. This is first described in eukaryotes. Figure:Hypothetical model of the regulation of retinoic acid(RA) action(George Zhu,1991, revised in 2012)
会议名称:

再造生命之泉 滋养生命之树——2013第二届血液病学大会

会议时间:

2013-05-23

会议地点:

中国陕西西安

  • 专辑:

    医药卫生科技

  • 专题:

    心血管系统疾病; 肿瘤学

  • 分类号:

    R733

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