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摘要:NBM-T-L-BMX-OS01(BMX) was derived from the semi-synthesis of osthole,isolated from Cnidium monnieri(L.) Cusson.The BMX was identified as a potent inhibitor of HDAC,and enhanced memory formation.Because HDAC was highly expressed in the brain,particularly in motor-coordination areas,the effects of BMX on motor-related disorders(such as PD) were examined.BMX exhibited scavenging 2-diphenyl-1-picrylhydrazyl(DPPH) radical activities and ameliorated H2O2-induced neurosphere death.Suberoylanilide hydroxamic acid(SAHA) was selected as a control.BMX and SAHA prevent l-methyl-4-phenylpyridinium(MPP+)-induced cytotoxicity and l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine(MPTP)-induced rotarod performance impairment in animals.BMX reversed the increase of MPTP-induced p-38 phosphorylation and inducible nitric oxide synthase(iNOS) expression.SAHA reversed the reduction of tyrosine hydroxylase(TH)levels by MPTP.The results indicate that BMX and SAHA exhibit protective and therapeutic potential in PD mice,through various mechanisms.
会议名称:

2014第五届国际神经科技大会——主题:从未解之谜到市场

会议时间:

2014-05-16

会议地点:

中国江苏南京

  • 专辑:

    医药卫生科技

  • 专题:

    基础医学; 神经病学

  • 分类号:

    R742.5;R-332

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