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Pharmacological Activity of Cancer Chemoprevention by Mangiferin Using Transcriptome Pathway Analysis in Colon Tumor Models

Rene Delgado-HernandezIvones Hernández-BalmasedaJulio C.RodriguezIdaniaRodeiro-GuerraKen DeclerckKen Op de BeeckStefan NaulaertsGuy Van CampOlga L.QuinonesGuy HaegemanWim Vanden Berghe

Drug Research and Development Center(CIDEM)

摘要:Cancer is a multigenic disease associated to chronic inflammation,which in turn is associated to oxidative stress.The main problems of the anti-cancer chemotherapy are their lack of specificity and their serious adverse effects.The identification of biologically active compound from natural products has been a long-term focus in the pharmaceutical industry.The natural compounds capable of increasing the defenses of the human organism should at least,diminish the adverse effects of classical anticancer drugs.Mangiferin is a glucosilxanthone,which has been known for its antioxidant,immunomodulatory,antitumoral and anti-inflammatory actions.In this way,we apply bioinformatics methods to identify multiple targets of the gene expression profiles analysis following in vivo treatment.By using transcriptome based pathway analysis,it was possible to identify activated or repressed pathways and to predict possible molecular targets in CT-26.WT murine colon carcinoma syngeneic tumor models.The antitumor and antimetastatic effects were positively correlated with increasing doses of mangiferin,showing the greatest effect at 100 mg/kg.Pathway enrichment analysis revealed that mangiferin targeted specific cancer processes related to cell death and survival,cellular growth and proliferation,inflammatory and oxidative response.Mangiferin holds promise as an effective antitumor agent by triggering antimetastatic and antiangiogenic effects.
会议名称:

抗癌策略新思路——2016第九届世界癌症大会

会议时间:

2016-05-14

会议地点:

中国上海

  • 专辑:

    医药卫生科技

  • 专题:

    药学

  • 分类号:

    R96

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