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摘要:Pangolins,unique mammals with scales over most of their body,no teeth,poor vision,and an acute olfactory system,comprise the only placental order(Pholidota) without a whole-genome map.To investigate pangolin biology and evolution,we developed genome assemblies of the Malayan(Manisjavanica) and Chinese(M.pentadactyla) pangolins.Strikingly,we found that interferon epsilon(IFNE),exclusively expressed in epithelial cells and important in skin and mucosal immunity,is pseudogenized in all African and Asian pangolin species that we examined,perhaps impacting resistance to infection.We propose that scale development was an innovation that provided protection against injuries or stress and reduced pangolin vulnerability to infection.Further evidence of specialized adaptations was evident from positively selected genes involving immunity-related pathways,inflammation,energy storage and metabolism,muscular and nervous systems,and scale/hair development.Olfactory receptor gene families are significantly expanded in pangolins,reflecting their well-developed olfaction system.This study provides insights into mammalian adaptation and functional diversification,new research tools and questions,and perhaps a new natural IFNE-deficient animal model for studying mammalian immunity.
会议名称:

2017第八届国际DNA和基因组活动周——2017第二届国际遗传学大会&2017第一届国际生物技术产业大会

会议时间:

2017-04-25

会议地点:

中国陕西西安

  • 专辑:

    基础科学

  • 专题:

    生物学; 生物学

  • 分类号:

    Q953

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