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Retroelements:Do They Play General Roles in Oncogenesis?

Adam S.Wilkins

Institute of Theoretical Biology Humboldt University zu Berlin Germany

摘要:Retroelements,the derivatives of ancient retroviruses,comprise a major part of the human genome.Long regarded as simply "junk DNA",it is now clear that many have evolved to play roles in the regulation of various genes.Furthermore,when activated,some at least play active roles in various pathological conditions,especially cancer.Most analyses of their roles in cancer,however,focus on the consequences of their transposition and insertion into novel sites following activation.In contrast,I argue that their activation can be important in cancer in two ways distinct from transposition.First,I proposethat their initial transcriptional activation,which can be triggered by many different environmental inputs,can have important epigenetic effects on neighboring genes,either activating oncogenes or repressing tumor suppressors,in either case initiating tumorigenesis.Second,I argue that retroelements play key roles in the chromosome breaks and rearrangements that are a cardinal characteristic of later stages of cancer development.This dual-role hypothesis was published in2010.Here,I will review and discuss morerecently published evidence that supports this idea.
会议名称:

BIT’s 10th Annual World Cancer Congress-2017

会议时间:

2017-05-19

会议地点:

Barcelona, Spain

  • 专辑:

    医药卫生科技

  • 专题:

    肿瘤学

  • 分类号:

    R730.2

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