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摘要:Studies about leukocytapheresis(LCAP) have emerged with the need of search for alternatives to conventional treatment in inflammatory bowel diseases(IBD).LCAP is a novel non-pharmacologic approach for active ulcerative colitis(UC) and Crohn’s disease(CD),in which leukocytes are mechanically removed from the circulatory system.Patients with active IBD treated with LCAP using a Cellsorba E column between 2012 and 2017,were enrolled in Turkey.In our experience,the results of LCAP therapy in 16 patients with CD and 23 patients with active UC were overviewed(Table 1 and 2).LCAP(10 sessions for remission induction therapy,6 sessions for maintenance therapy) was applied to the patients with their concomitant medications.Clinical remission was observed in 82.6%of patients with UC after 10 sessions LCAP(Figure 1 and 2).20 patients with UC were followed for an average of 24 months.The overall clinical remission rate in these patients was 80%,and the mucosal healing rate was 65%.It was observed that clinical remission has continued in 65%of patients with UC.Mild relapse was observed in 3 patients with UC during follow up period.(Figure 3 and 4).The overall clinical remission rate in patients with CD(n=16) was 81.2%,and the mucosal healing rate was 68.8%after 10 sessions of LCAP(Figure 5,6 and 7).6 patients with CD were followed for an average of 24 months.In 5 patients with CD significant clinical remission was achieved except only one patient.Surgical needs were disappeared in 3 patients with obstructive type CD.Adverse events were seen in only 4.5%of 576 sessions.Any concomitant medications did not increase the incidence of adverse events.Our results indicate that LCAP is efficacious in improving remission rates with excellent tolerability and safety in patients with IBD.Our results indicate that LCAP is efficacious in improving remission rates with excellent tolerability and safety in patients with IBD.
会议名称:

BIT’s 2nd Annual World Congress of Digestive Disease-2017

会议时间:

2017-12-04

会议地点:

Fukuoka, Japan

  • 专辑:

    医药卫生科技

  • 专题:

    消化系统疾病

  • 分类号:

    R574.62

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