Microwave Assisted Synthesis of Some 2-Amino-3-（p-Fluorocarboxanilido）-6-Methyl piperidino[4,3-b] Thiophenes and Their Antibacterial Evaluation
Prabodh Chander Sharma1Archana Sharma1Dalbir Singh2Om Prakash Sharma3
1. Institute of Pharmaceutical Sciences,Kurukshetra University,Kurukshetra-136119,INDIA2. Department of Pharmacy,Government Polytechnic,Utawar-121001,INDIA3. Department of Pharmacy,Government Polytechnic,Adampur-125052,INDIA
摘要：Synthesis of a series of 2-substituted-3-（p-fluorocarboxanilido）-6-methyl piperidino（4,3-b） thiophenes has been carried out by microwave irradiation method.The microwave methods effectively reduced the reaction time from 3-4 h（conventional method） to a few minutes（1.0-1.5 min）.Highest yield improvement of about 82% was observed for compound IIIc.All the compounds were characterized by using spectral and analytical techniques.All the compounds were screened for their antibacterial activity and showed moderate to significant activities.
International Conference on Bioscience, Biochemistry and Bioinformatics（ICBBB 2011）