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Microwave Assisted Synthesis of Some 2-Amino-3-(p-Fluorocarboxanilido)-6-Methyl piperidino[4,3-b] Thiophenes and Their Antibacterial Evaluation

Prabodh Chander Sharma1Archana Sharma1Dalbir Singh2Om Prakash Sharma3

1. Institute of Pharmaceutical Sciences,Kurukshetra University,Kurukshetra-136119,INDIA2. Department of Pharmacy,Government Polytechnic,Utawar-121001,INDIA3. Department of Pharmacy,Government Polytechnic,Adampur-125052,INDIA

摘要:Synthesis of a series of 2-substituted-3-(p-fluorocarboxanilido)-6-methyl piperidino(4,3-b) thiophenes has been carried out by microwave irradiation method.The microwave methods effectively reduced the reaction time from 3-4 h(conventional method) to a few minutes(1.0-1.5 min).Highest yield improvement of about 82% was observed for compound IIIc.All the compounds were characterized by using spectral and analytical techniques.All the compounds were screened for their antibacterial activity and showed moderate to significant activities.
会议名称:

International Conference on Bioscience, Biochemistry and Bioinformatics(ICBBB 2011)

会议时间:

2011-02-26

会议地点:

Singapore

  • 专辑:

    理工B(化学化工冶金环境矿业)

  • 专题:

    有机化工

  • 分类号:

    TQ463.5

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