Association of plasma β-amyloid 40 and 42 concentration with type 2 diabetes among Chinese adults
摘要：Objective We aimed to investigate the association of plasma β-amyloid 40（Aβ40） and Aβ42, potential biomarkers for AD, with risk of T2D. Methods We performed a case-control study and a nested case-control study. In the case-control study, we included 1063 newly diagnosed T2D cases and 1063 controls matched by age and sex. In the nested case-control study, we included 121 incident T2D cases and 242 matched controls. Plasma Aβ40 and Aβ42 concentrations were measured with electrochemiluminescence immunoassay. Conditional logistic regression was used to evaluate the association. Results Higher plasma Aβ40 and Aβ42 concentrations were associated with higher odds of T2D in both two studies. The pooled multivariable-adjusted odds ratios（ORs） of T2D comparing the highest with the lowest quartile of plasma Aβ concentrations were 2.16（95% CI: 1.64, 2.85） for plasma Aβ40 and 2.12（95% CI: 1.62, 2.78） for plasma Aβ42. Each standard deviation increment of ln-transformed plasma Aβ40 and Aβ42 were associated with 33%（95% CI: 21%, 47%） higher odds of T2D. Subjects in the highest tertile of both plasma Aβ40 and Aβ42 concentrations had 3-fold greater odds of T2D compared with those in the lowest tertile of both plasma Aβ40 and Aβ42 concentrations（pooled P for interaction = 0.010）. Conclusions Our findings suggested positive associations of plasma Aβ40 and Aβ42 concentration with risk of T2D. Further studies are warranted to elucidate the underlying mechanism and explore the potential roles of plasma Aβ in linking T2D and AD.