Prevention of osteoporosis by nutrigenomic guidance of obese postmenopausal women
Kagawa Nutrition UniversityTohto UniversityNutrition Clinic,Kagawa Nutrition University Nutrition ClinicDepartment of Food and Nutrition Faculty of Human Life,Jumonji UniversityDepartment of Integrated Biosciences,Graduate School of Frontier Sciences,The University of Tokyo
摘要：Objective is nutrigenomic body mass index（BMI） reduction without bone mineral density（BMD） loss for postmenopausal women. Methods The study design was a before-and-after trial without osteoporosis drug for 79 postmenopausal obese women（60 ± 6 years; mean BMI, 27.6 kg/m~2）, and primary evaluation outcomes were BMD, BMI and bone alkaline phosphatase（BAP）. BMD was measured by X-ray absorptiometry, and bone formation was measured with BAP. Five risk single nucleotide polymorphisms（SNPs） for fracture detected by genomewide association studies（GWAS）（FONG rs 7605378, FAM3C rs 7776725, MECOM rs 784288, ALDH2 rs 671）, and risk SNPs for obesity（ADRB3 rs4994, UCP1 rs 1800592）, hypertension（AGT rs699） and folate metabolism（MTHFR rs1801333） were determined by TaqMan Genotyping. Results Subjects were notified of the SNPs as motivation to increase their folate intake（to 400 μg/day）, and to reduce their intake of salt（to ＜6 g/day）, energy（to BMI=25） and ethanol（to 0 g/day）, because homocysteine, Na, visceral obesity and aldehyde, respectively, are harmful to BMD. With weight reduction of 4.4%, BMI reduced to 26.5 kg/m~2（p＜0.01） and BMD was maintained to 1.013±0.105 g/cm~2（p=0.152）. BAP increased from 15.8 μg/L to 17.1 μg/L（p=0.016）. BMD of GA heterozygotes of ALDH2 was less than that of GG homozygotes（p=0.036）, but sobriety resulted in BMD maintenance. Only in subjects with T-allele of MTHFR serum folate increased, and those with T-allele of AGT, Na intake was reduced by the genome notification. Conclusions Obese postmenopausal women were motivated by risk SNPs notification, BMI was reduced without BMD decrease and with BAP increase.