Paternal body mass index before conception associated with offspring’s birth weight in Chinese population: a prospective study
Department of Clinical Nutrition,Ren Ji Hospital,School of Medicine,Shanghai Jiao Tong UniversityDepartment of Obstetrics,Ren Ji Hospital,School of Medicine,Shanghai Jiao Tong UniversityDepartment of Nutritional Sciences,The Pennsylvania State University,University Park
摘要：Objective Animal studies have shown that parental epigenetic information of nutrition and behavior might be inherited by subsequent generation. However, relevant human evidence has been limited to date. We thus performed a longitudinal study to evaluate the relationship between paternal preconception body weight and their offspring’s birth weight. Methods The current analysis included 1,810 Chinese mother-father-baby trios. Information on paternal and maternal preconception body weight and height was collected via a self-reported question at the first prenatal check-up and classified into three groups: normal, overweight, and obese according to the Working Group of Obesity in China（WGOC） criteria for adults. Information on birth weight was collected by review of medical records. The relationship between paternal preconception body weight and his children’s birth weight was examined by generalized linear model, adjusting for maternal demographic data, preconception BMI, and gestational weight gain, and other potential confounders. Results Higher paternal preconception body weight was associated with greater offspring’s birth weight（p trend=0.02）. Per standard deviation（SD） increment of paternal BMI was associated with additional 29.6 g of birth weight [95% confident interval（CI）: 5.7, 53.5 g]. In subgroup analyses, the association between paternal body weight and offspring’s birthweight was more pronounced in male neonates, and neonates with overweight mothers and with mothers who gained excessive gestational, relative to their counterparts（all p interaction<0.05）. Conclusions Greater paternal preconception body weight was associated with greater birth weight of their offspring.