The risk of missed abortion associated with the levels of PAEs and its metabolits in blood and villi tissue of pregnant woman
摘要：Objective By questionnaire investigation and laboratory tests, to analysis the association between missed abortion and phthalic acid esters exposure and the relationship of plasma and villus tissue at the leves of PAEs and its metabolites. Methods This was a case-control study. 121 cases of missed abortion patients were recuited.At the same time, 98 cases of voluntary abortion of pregnant women were recuited as control group. Through questionnaire investigation learned about the basic information of the study objects. The levels of 10 kinds of PAEs and its metabolites in the plasma and villi tissue were tested. The questionnaire information was input using EpiData software. The association between missed abortion and phthalic acid esters exposure and the relationship of plasma and villus tissue at the leves of PAEs were analyzed by SPSS 16.0 software. Results The logistic analysis revealed that age [Odds Ratio（OR） 1.162, 95% confidence interval（CI） 1.079-1.251], BMI（OR1.472,95% CI 1.234-1.756）, colouring and perming（OR 3.905, 95% CI 1.588-9.603）, passive smoke（P=0.048, OR 2.200, 95%CI 1.008-4.803）, MBzP（OR 3.600, 95% CI 1.659-7.812）, DEHP（OR 3.111, 95% CI 1.437-6.737）, DBP（OR 2.707, 95% CI 1.287-5.694） were important factors contributing to the missed abortion（P<0.05）. Conclusions High gestational age, high BMI, colouring and perming, passive smoke and phthalate exposure during pregnancy were the risk factors for missed abortion. Avoiding these harmful substances before getting pregnant and during the early stages of pregnancy, might help prevent missed abortions.