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摘要:Adiponectin is an adipocyte-secreted protein exhibiting insulin-sensitizing, anti-diabetic, anti-inflammatory and anti-atherogenic properties. Here we investigated whether exercise-elicited antidepressant effects are potentially mediated by adiponectin through its regulation on hippocampal neurogenesis. ADN deficient and wildtype mice were subjected to wheel running for 14 days. Immunostaining for bromodeoxyuridine, doublecortin and Ki67 were used to examine changes in hippocampal cell proliferation and differentiation. Depressive phenotypes of the mice were examined using forced swim test, tail suspension test and sucrose preference test. Hippocampal progenitor cell culture and neuroblastoma cell line were used to examine the related downstream pathways. Adiponectin could entry into the brain from blood stream. Increasing its levels in the brain resembled running in increasing cell proliferation and decreasing depressive-like behaviors. Adiponectin deficiency diminished exercise-increased hippocampal neurogenesis and-reduced depression-like behaviors. In vitro analyses indicated that adiponectin increased cell proliferation in both hippocampal progenitor cells and N2 a cells. The neurogenic effects of adiponectin were mediated by the adiponectin receptor 1(ADNR1), as siRNA targeting ADNR1, but not ADNR2, inhibited the capacity of adiponectin to enhance cell proliferation. These data suggest that adiponectin may play a significant role in mediating the effects of exercise on hippocampal neurogenesis and depression.
会议名称:

第四届国际神经再生高峰论坛(INRS2014)暨第九届亚太神经再生论坛(APSNR2014)暨第六届脊髓损伤治疗与临床试验国际交流会(ISCITT2014)

会议时间:

2014-09-06

会议地点:

中国江苏南京

  • 专辑:

    医药卫生科技

  • 专题:

    神经病学

  • 分类号:

    R741

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