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Numerical Simulation of Skin Formation: The Relationship between Transepidermal Water Loss and Corneum Thickness

Katsuya NagayamaTakeshi Kurihara

Department of Mechanical Information Science and Technology, Kyushu Institute of Technology

摘要:Skin moisturizing has drawn attention in terms of beauty and anti-aging industries.However, it is difficult to observe the inside of the epidermis and the relationship between the epidermis and water content is not yet clear.Computational simulations can be useful in understanding such mechanisms of skin formation.A particle model was used to simulate three-dimensional skin turnover, and the results reproduced the epidermal skin turnover phenomenon.In this study, a diffusion model is introduced into this simulation model and a moisture diffusion analysis of the epidermis was performed.In particular, transepidermal water loss(TEWL) was modeled by considering diffusion and surface evaporation in the stratum corneum and other layers.The relationship between the moisture content and the keratin detachment was considered, and the exfoliation condition of keratin based on the moisture content was calculated in the model.As a result, it was possible to calculate the intraepidermal water content distribution in the skin using the particle model.It was also possible to reproduce phenomena such as keratin thickening due to increase of TEWL.This phenomenon is consistent with cases of dry skin.In the future, it will be necessary to introduce a change in TEWL according to the thickness of the stratum corneum and the diffusion coefficient.
会议名称:

Workshop 8 2018

会议时间:

2018-08-21

会议地点:

中国云南昆明

  • 专辑:

    工程科技Ⅰ辑

  • 专题:

    一般服务业

  • 分类号:

    TS974.1

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