Hepatoprotetive, Cardioprotective and Nephroprotective Actions of Essential Oil Extract of Artemisia Sieberi in Alloxan-Induced Diabetic Rats
摘要：The aim of current study is to evaluate the potential mechanism of antidiabetic action of the essential oil of Artemisia sieberi and its effects on some hematological and biochemical parameters in alloxan induced diabetic rats. Extraction of essential oil from aerial parts of A. sieberi was preformed by hydrodistillation. Fifty rats were divided into five groups. Groups I and II normal rats given 1 ml/day of dimethyl sulfoxide and 80 mg/kg bw of this oil extract, respectively. Groups III, IV and V diabetic rats given 1 ml/day of dimethyl sulfoxide, oil extract （80 mg/kg bw） and metformin （14.2 mg/kg bw）, respectively. Several hematological and biochemical parameters were assessed. Oral administration of the extract resulted in a significant reduction in the mean values of blood glucose, glucagon, cholesterol, triglyceride, LDL-C, ESR, urea, uric acid, creatinine accompanied by an increase in the mean values of total protein, albumin, insulin, HDL-C, neutrophile count and PCV in diabetic rats. No significant changes in these parameters were found in the control group. The effects produced by this extract were closely similar to a standard antidiabetic drug, metformin. In conclusion, the present study indicates that the essential oil extract of A. sieberi appears to exhibit cardioprotective, nephroprotective and hepatoprotective activities in alloxan induced diabetic rats.
International Conference on Computational Techniques and Artificial Intelligence（ICCTAI’2011）;International Conference on Advances in Electrical and Electronics Engineering（ICAEE’2011）;International Conference on Mechanical,Automobile and Robotics Engineering（ICMAR’2011）;International Conference on Management,Behavioral Sciences and Economics Issues（ICMBSE’2011）;International Conference on Chemical,Environmental and Biological Sciences（ICCEBS’2011）;International Conference on Biotechnology and Pharmaceutical Sciences（ICBPS’2011）