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Inhibition of Mycoparasitic Growth by Filamentous Nonpolyne Chitinolytic Producing Bacteria

Abdullah Y. Al-MahdiQaees Y. M. AbdullahAnas A. Al-MahbashiAbdulrahman A. HomedSalwa H. Al-KaeatSaeed M. Al-Galibi

Microbiology Branch,Department of Biology,Faculty of Science,University of Sana’a,Sana’a,Yemen.

摘要:Fatty acids like ergosterol and tween 80 are depressing the inhibition of mycoparasitic activity of polyene antibiotics by neutralizing effect. Polyene antibiotics become bound to the fungal cell membrane and cause permeability changes with attendant depletion of essential cellular constituents. Loss of potassium and ammonium ions, inorganic phosphate, carboxylic acids, sugar phosphates, nucleotides and protein have been shown to occur in several fungal species after exposure to polyene antibiotics. Most polyene antibiotics are toxic to human and therefore used predominantly in topical applications. Kidney damage is a major problem when polyene is used systemically to treat several fungal infections. Since polyene macrolides are produced by actinomycetes, particularly Streptomyces, from 149 chitinolytic producing actinomycetes isolated where are 72% of isolates have been produce polyene antifungal antibiotics which their activity effected by ergosterol and tween 80, this method allows the analysis of a greater number of strains at an early stage of the screening procedure. We selected 20 isolates which showed maximum zone of inhibition, from both non-polyene and polyene antibiotic, which belonged Streptomyces or other genera for further investigation to detect novel antifungal antibiotics and novel chitinolytic producing actinomycetes.
会议名称:

International Conference on Latest Computational Technologies(ICLCT’2012);International Conference on Biotechnology,Nanotechnology and its applications(ICBNA’2012);International Conference on Mechanical, Electronics and Mechatronics Engineering(ICMEME’2012);International Conference on Humanities,Economics and Geography(ICHEG’2012);International Conference on Chemical,Ecology and Environmental Sciences(ICEES’2012);International Conference on Medical,Biological and Pharmaceutical Sciences(ICMBPS’2012)

会议时间:

2012-03-17;2012-03-17;2012-03-17;2012-03-17;2012-03-17;2012-03-17

会议地点:

Bangkok,Thailand;Bangkok,Thailand;Bangkok,Thailand;Bangkok,Thailand;Bangkok,Thailand;Bangkok,Thailand

  • 专辑:

    工程科技Ⅰ辑

  • 专题:

    一般化学工业

  • 分类号:

    TQ925

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