Expression of CRM1 and Her-2/neu and Their Clinical Significance in Gastric Cancer
摘要：The aim of the study was to investigate the expression levels of CRM1 and Her-2/neu in gastric cancers and the corresponding normal tissues, correlation with their clinicopathological parameters and the relationship of CRM1 and Her-2/neu in the metastasis and occurrence gastric carcinoma. 135 postoperative patients were examined for CRM1 expression by immunohistochemistry and for Her-2/neu expression by fluorescence in situ hybridization（FISH）. The positive expression rate of CRM1 in neoplastic tissues and adjacent gastric mucosa were 57.8% and 6.7% respectively. CRM1 levels were linked to more advanced tumor stages, poor prognosis, and likelihood of recurrence（P<0.05）. The Cox multivariate analysis indicated that the CRM1 expression was an independent indicator for tumor recurrence（P=0.0048）. 16 of the 135 gastric cancer specimens（11.85%） were positive for Her-2/neu, the expressions were not found in paired normal tumor-adjacent. Positive cases for Her-2/neu also had high CRM1 expression levels（P=0.0104）. The current results suggest that CRM1 is expressed in gastric carcinomas and is related to poor patient outcome, and Her-2/neu has no relationship with the prognosis of GC. The relationship of CRM1 and Her-2/neu expression in gastric cancer may be benefit for selection therapeutic approaches.