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摘要:The aim of the study was to investigate the expression levels of CRM1 and Her-2/neu in gastric cancers and the corresponding normal tissues, correlation with their clinicopathological parameters and the relationship of CRM1 and Her-2/neu in the metastasis and occurrence gastric carcinoma. 135 postoperative patients were examined for CRM1 expression by immunohistochemistry and for Her-2/neu expression by fluorescence in situ hybridization(FISH). The positive expression rate of CRM1 in neoplastic tissues and adjacent gastric mucosa were 57.8% and 6.7% respectively. CRM1 levels were linked to more advanced tumor stages, poor prognosis, and likelihood of recurrence(P<0.05). The Cox multivariate analysis indicated that the CRM1 expression was an independent indicator for tumor recurrence(P=0.0048). 16 of the 135 gastric cancer specimens(11.85%) were positive for Her-2/neu, the expressions were not found in paired normal tumor-adjacent. Positive cases for Her-2/neu also had high CRM1 expression levels(P=0.0104). The current results suggest that CRM1 is expressed in gastric carcinomas and is related to poor patient outcome, and Her-2/neu has no relationship with the prognosis of GC. The relationship of CRM1 and Her-2/neu expression in gastric cancer may be benefit for selection therapeutic approaches.
会议名称:

2014年肿瘤机制研究国际研讨会

会议时间:

2014-07

会议地点:

中国山东青岛

  • 专辑:

    医药卫生科技

  • 专题:

    肿瘤学

  • 分类号:

    R735.2

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