记笔记

Formulation and In Vitro Evaluation of Cimetidine Microsphere as Gastro Retentive Floating Drug Delivery System

Mokale VinodNaik JitendraShirude PriyankaShimpi Navin

Department of Pharmaceutical Technology, University Institute of Chemical Technology （UICT）, North Maharashtra University

摘要：Context: The purpose of this work was preparation and evaluation of floating microsphere using cimetidine （CM） as a model drug by solvent evaporation method （O/O）. Objective is to achieve an extended retention of floating microsphere using cimetidine （CM） microspherein the upper GIT followed by enhanced absorption and improved bioavailability. Methods: The microspheres were prepared by the solvent evaporation method using different ratios of polymers like hydroxy propyl methyl cellulose and ethyl cellulose. Results: The prepared Cimetidine microspheres were evaluated for FTIR and XRD study and found no interaction between drug and excipients, entrapment efficiency was found to be 91.12%, microspheres was spherical in shape with smooth surface in micro size it reveals by surface morphology （FE-SEM） and in vitro drug release study shown 79.6% drug release within 12 hrs. Conclusion: In vitro study of polymer encapsulated Cimetidine shown good buoyancy and entrapment efficiency along with decrease in dosing frequency.

关键词：

Floating microsphere; Hydroxypropyl methyl cellulose; ethyl cellulose; solvent evaporation （O/O）.;

基金：

University Grants Commission（UGC）, New Delhi, Govt. of India, for providing financial support [F. No. 39-960/2010 （SR）]；

会议名称：

International Conference on Law,Literature and Management（ICLLM’13）;International Conference on Environment and Geological Systems（ICEGS’13）;International Conference on Agriculture and Food Engineering（ICAFE’13）;International Conference on Chemical Engineering and Physical Sciences（ICCPS’13）;International Conference on Biomedical and Pharmaceutical Sciences（ICBPS’13）;International Conference on Mechatronics and Manufacturing Engineering（ICMME’13）; International Conference on Advanced Computing and Information Technology（ICACIT’13）

会议时间：

2013-10-10;2013-10-10;2013-10-10;2013-10-10;2013-10-10;2013-10-10;2013-10-10

会议地点：

Batam Island,Indonesia;Batam Island,Indonesia;Batam Island,Indonesia;Batam Island,Indonesia;Batam Island,Indonesia;Batam Island,Indonesia;Batam Island,Indonesia

专辑：
理工B(化学化工冶金环境矿业); 医药卫生
专题：
有机化工; 药学
分类号：
R944

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Formulation and In Vitro Evaluation of Cimetidine Microsphere as Gastro Retentive Floating Drug Delivery System

Mokale VinodNaik JitendraShirude PriyankaShimpi Navin

Department of Pharmaceutical Technology, University Institute of Chemical Technology （UICT）, North Maharashtra University

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