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摘要:Maternal undernutrition or overnutrition during pregnancy impairs prenatal and neonatal growth and development,and also reduces feed efficiency for lean tissue gains in pigs.These adverse effects may be carried over to the next one or more generations.This phenomenon of the transgenerational impacts is known as fetal programming,which is mediated by stable and heritable alterations of gene expression through covalent modifications of DNA and histones without changes in DNA sequences(namely,epigenetics).The mechanisms responsible for epigenetic regulation of protein expression and functions include chromatin remodeling;DNA methylation(occurring at the 5’-position of cytosine residues within Cp G dinucleotides);and histone modifications(acetylation,methylation,phosphorylation,and ubiquitination).Like maternal malnutrition,undernutrition during the neonatal period also reduces growth performance and feed efficiency(weight gain:feed intake) in postweaning pigs by 5-10%,thereby increasing the days necessary to reach the market body-weight.Supplementing functional amino acids(e.g.,arginine and glutamine) and vitamins(e.g.,folate) play key roles in activating the mammalian target of rapamycin signaling and regulating the provision of methyl donors for DNA and protein methylation.Therefore,these nutrients are beneficial for the dietary treatment of metabolic disorders in offspring with intrauterine growth restriction or neonatal malnutrition.The mechanism-based strategies hold great promise to improve the efficiency of pork production and the sustainability of the global swine industry.
会议名称:

2016第三届中国·猪营养国际论坛

会议时间:

2016-10-19

会议地点:

中国上海

  • 专辑:

    农业科技

  • 专题:

    畜牧与动物医学

  • 分类号:

    S828

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