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摘要:Among a large variety of nitrogen-containing heterocyclic compounds,heterocyclic containing hydrazine has received considerable attention because of their pharmacological properties and clinical applications.Phthalazine ring was an important bioactive core found in many agents of biological as anti-convulsive,anti-inflammatory,anti-tumor and vascular endothelial growth factor receptor(VEGFR-2) inhibitory.Schiff base fragments are also frequently used in the synthesis of anti-tumor small molecules.In this paper,phthalic anhydride as a starting material,through cyclization,chlorination,substitution and condensation reactions to get a series of target compounds were designed and synthesized.All the compounds have been confirmed by 1 H-NMR、13C-NMR and MS.Currently,the anti-tumor activity of these compounds are being tested.
会议名称:

第11届世界华人药物化学研讨会(ISCMC 2018)

会议时间:

2018-08-24

会议地点:

中国河南郑州

  • 专辑:

    医药卫生

  • 专题:

    药学; 药学

  • 分类号:

    R914;R96

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