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摘要:Our recent studies demonstrated that NgBR is an essential gene for development because NgBR genetic depletion causes the early embryonic lethality.We utilized tissue-specific knockout approaches to further determine the roles of NgBR in development and pathogenesis of vascular and metabolic diseases.Endothelial cell-specific knockout of NgBR resulted in the cerebrovascular malformation and contributed to the pathogenesis of cerebral cavernous malformation[1].Genetic depletion of NgBR in the liver increased the biosynthesis of fatty acid and facilitated the pathogenesis of non-alcoholic fatty liver diseases(NAFLD).Our recent publication demonstrated that NgBR is required for the translocation of Ras to the plasma membrane,which is a critical step for activating RTKs-mediated signalling pathways.Consequently,NgBR is highly expressed in many tumor cells and involved in developing the resistance to conventional therapy and promoting tumor metastasis through the epithelial-mesenchymal transition(EMT) and tumor angiogenesis.To determine if NgBR is an effective target for cancer therapy,we developed a surface charge switchable polymeric nanoparticle that was sensitive to the slightly acidic tumor microenvironment for steady delivery of small interfering RNAs(siRNA) against NgBR to tumor-bearing tissues.Delivery of the NgBR-siRNA nanoformula to the mice bearing orthotropic breast carcinoma led to the remarkable decrease of distant metastasis by normalizing tumor vessels and suppressing the EMT of breast cancer cells.
会议名称:

The 3rd International Conference on Nanomedicine of China(ChinaNanomedicine 2018)

会议时间:

2018-10-15

会议地点:

中国上海

  • 专辑:

    基础科学; 医药卫生科技

  • 专题:

    生物学; 生物医学工程

  • 分类号:

    R318

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