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摘要:Objective: Memories for substance abuse can be decreased by pharmacological interference after conditioned stimulus-induced memory reactivation(CS-MR). However, the procedure has limitations for "real world" relapse prevention, since the disruptive effect of the procedure is selective to the reactivated cues and does not generalize to other cues that have not been reactivated. In the present study, we investigated whether pharmacological interference after unconditioned stimulus-induced memory reactivation(US-MR) erase all nicotine-associated memory traces. Methods: In animal studies, rats were trained for pavlovian nicotine-associated memory with conditioned place preferences(CPP) and instrumental nicotine-associated memory with self-administration model. Memory was reactivated by exposure to previous nicotine-associated cues(as CS-MR) or a low dose of nicotine(as US–MR). In human study, smokers were trained for the association between pictures on the computer screen and smoking tobaccos. Memory reactivation was induced by smoking tobacco. Results: We found that cerebral ventricular microinjections of inhibitors of protein synthesis immediately after but not 9 h after CS-MR or US-MR disrupted subsequent recall of nicotine CPP memory. We also confirmed the phenomenon in instrumental nicotine-associated memory(nicotine self-administration). Subsequently, we found systemic administration of propranolol, an antagonist of adrenergic β-receptor, immediately after US-MR disrupted subsequent recall of nicotine CPP memory or nicotine self-administration memory. Furthermore, when rats were trained for two types of nicotine-associated memories(i.e. CPP memory and self-administration memory), systemic administration of propranolol immediately after US-MR disrupted subsequent recall of both of them, while propranolol administration immediately after CS-MR only disrupted subsequent recall of the memory reactivated previously. Lastly, after smokers learned the association between smoking tobaccos and two associated cues, oral administration of propranolol one hour before US-MR also decreased all the smoking-associated memories, including new learned cue memories and existing cue memories in real world. Conclusion: Our findings indicate that pharmacological interferences after US-MR lead to erasure of all nicotine-associated memory traces, and the US-MR-targeting inhibition may be a new strategy for the treatment of nicotine relapse.
会议名称:

第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议

会议时间:

2015-09-20

会议地点:

中国浙江桐乡

  • 专辑:

    医药卫生科技

  • 专题:

    精神病学

  • 分类号:

    R749.61

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