文献知网节
  • 记笔记
摘要:The transient receptor potential X(TRP-X) is a non-selective cation channel implicated in physiological relevance. Here we show that TRP-X elevates intracellular Ca2+ concentration([Ca2+]i) in dorsal root ganglion(DRG) neurons not only in the presence but also in the absence of extracellular Ca2+. Pharmacological and immunocytochemical analyses revealed the presence of TRP-X on both the plasma membrane and in a nonER organelle(n ER). Confocal line-scan imaging demonstrated a close association of Ca2+ signals elicited by TRP-X activation with individual n ER("n ER Ca2+ spark"). In physiological solutions, the TRP-X mediated lysosomal Ca2+ release contributed to 40% of the overall [Ca2+]i rise and directly triggered vesicle exocytosis and neuropeptide release. The n ER-localized TRP-X in DRG neurons also modulated TRP-X agonistinduced pain response and heat hyperalgesia in wild type but not TRP-X-deficient mice. Thus, in addition to working via Ca2+ influx, TRP-X triggers vesicle exocytosis in sensory neurons and modulates pain sensation by releasing Ca2+ from non-ER.
会议名称:

第九届亚洲生物物理大会

会议时间:

2015-05-09

会议地点:

中国浙江杭州

  • 专辑:

    基础科学

  • 专题:

    生物学

  • 分类号:

    Q42

  • 手机阅读
    即刻使用手机阅读
    第一步

    扫描二维码下载

    "移动知网-全球学术快报"客户端

    第二步

    打开“全球学术快报”

    点击首页左上角的扫描图标

    第三步

    扫描二维码

    手机同步阅读本篇文献

  • HTML阅读
  • CAJ下载
  • PDF下载

下载手机APP用APP扫此码同步阅读该篇文章

下载:1 页码:222 页数:1 大小:209k

引文网络
  • 参考文献
  • 引证文献
  • 共引文献
  • 同被引文献
  • 二级参考文献
  • 二级引证文献
  • 批量下载
相关推荐
  • 相似文献
  • 读者推荐
  • 相关基金文献
  • 相关法规
  • 关联作者
  • 相关视频