Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes
Peng Xiao1,2Wei Yan1Lu GouYa-Ni Zhong2Liangliang KongChao Wu1Xin Wen2Yuan Yuan1Sheng CaoChangxiu Qu2Xin Yang1Chuan-Cheng Yang2Anjie Xia1Zhenquan HuQianqian ZhangYong-Hao He2Dao-Lai ZhangChao ZhangGui-Hua HouHuanxiang LiuLizhe ZhuPing Fu1Shengyong Yang1Daniel M.RosenbaumJin-Peng Sun2Yang DuLei ZhangXiao YuZhenhua Shao1
1. Division of Nephrology and Kidney Research Institute,State Key Laboratory of Biotherapy and Cancer Center,West China Hospital,Sichuan University2. Key Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology,School of Basic Medical Sciences,Cheeloo college of Medicine,Shandong University
摘要：<正>Dopamine receptors,including D1-and D2-like receptors,are important therapeutic targets in a variety of neurological syndromes,as well as cardiovascular and kidney diseases.Here,we present five cryo-EM structures of the dopamine D1 receptor（DRD1）coupled to Gs heterotrimer in complex with three catechol-based agonists,a noncatechol agonist,and a positive allosteric modulator for endogenous dopamine.These structures revealed that a polar interaction network is essential for catecholaminelike agonist recognition,
会议名称：
第十九次中国暨国际生物物理大会
会议时间：
2021-07-23
会议地点：
中国安徽合肥
- 专辑：
基础科学
- 专题：
生物学
- DOI：
10.26914/c.cnkihy.2021.058879
- 分类号：
Q617
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