记笔记

Mitocytosis,a migrasome-mediated mitochondrial quality control process

Haifeng Jiao¹Dong Jiang¹Xiaoyu Hu¹Wanqing Du¹Liangliang Ji²Yuzhuo Yang²Xiaopeng Li¹Takami Sho¹Xuan Wang¹Ying Li¹Yu-Ting Wu³Yau-HueiWei³Xiaoyu Hu²Li Yu¹

1. State Key Laboratory of Membrane Biology,Tsinghua University-Peking University Joint Centre for Life Sciences,Beijing Frontier Research Center for Biological Structure,School of Life Sciences,Tsinghua University 2. Institute for Immunology and School of Medicine,Tsinghua University 3. Center for Mitochondrial Medicine and Free Radical Research,Changhua Christian Hospital

摘要：Damaged mitochondria need to be cleared to maintain the quality of the mitochondrial pool.Here we report mitocytosis,a migrasome-mediated mitochondrial quality control process.We found that upon exposure to mild mitochondrial stresses,damaged mitochondria are transported into migrasomes and subsequently disposed of from migrating cells.Mechanistically,mitocytosis requires positioning of damaged mitochondria at the cell periphery,which occurs because damaged mitochondria avoid binding to inward motor proteins.Functionally,mitocytosis plays an important role in maintaining mitochondrial quality.Enhanced mitocytosis protects cells from mitochondrial stressor-induced loss of mitochondrial membrane potential（MMP） and mitochondrial respiration;conversely,blocking mitocytosis causes loss of MMP and mitochondrial respiration under normal conditions.Physiologically,we demonstrate that mitocytosis is required for maintaining MMP and viability in neutrophils in vivo.We propose that mitocytosis is an important mitochondrial quality control process in migrating cells,which couples mitochondrial homeostasis with cell migration.

关键词：

Mitochondrion; migrasome; mitocytosis; mitosome; mitochondrial quality control;

会议名称：

第十九次中国暨国际生物物理大会

会议时间：

2021-07-23

会议地点：

中国安徽合肥