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摘要:Damaged mitochondria need to be cleared to maintain the quality of the mitochondrial pool.Here we report mitocytosis,a migrasome-mediated mitochondrial quality control process.We found that upon exposure to mild mitochondrial stresses,damaged mitochondria are transported into migrasomes and subsequently disposed of from migrating cells.Mechanistically,mitocytosis requires positioning of damaged mitochondria at the cell periphery,which occurs because damaged mitochondria avoid binding to inward motor proteins.Functionally,mitocytosis plays an important role in maintaining mitochondrial quality.Enhanced mitocytosis protects cells from mitochondrial stressor-induced loss of mitochondrial membrane potential(MMP) and mitochondrial respiration;conversely,blocking mitocytosis causes loss of MMP and mitochondrial respiration under normal conditions.Physiologically,we demonstrate that mitocytosis is required for maintaining MMP and viability in neutrophils in vivo.We propose that mitocytosis is an important mitochondrial quality control process in migrating cells,which couples mitochondrial homeostasis with cell migration.
会议名称:

第十九次中国暨国际生物物理大会

会议时间:

2021-07-23

会议地点:

中国安徽合肥

  • 专辑:

    基础科学

  • 专题:

    生物学; 生物学

  • DOI:

    10.26914/c.cnkihy.2021.058890

  • 分类号:

    Q244

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