Role of Endocannbinoids in Drug Addiction
Daniela ParolaroTiziana Rubino
Dept of Structural and Functional Biology,and Center of Neuroscience,University of Insubria,Via A,da Giussano 10,21052 Busto Arsizio （Varese）,Italy
摘要：<正> The presence of the endogenous cannabinoid system in reward circuits and its role in motivational and emotional homeostasis suggests that they might be involved in drug addiction. Animal models of drug reward provide evidence that the endogenous cannabinoids do have a role in the rewarding effect of several addictive drugs such as opioids. cocaine, alcohol, nicotine and psychostimulants. The pharmacological management of endocannbinoid signalling not only blocks the direct reinforcing effects of opioids. nicotine and ethanol, but also prevents relapse to the various drugs of abuse, including opioid. alcohol, cocaine and metamphetamine. Finally, as recently demonstrated. Delta -9 tetrahydrocannabinol and the non psy-choactive cannabidiol at low doses potentiated the extiction of cocaine and amphetamine place preference. This could be a new strategy to accelerate extinction, thus potentially reducing the likelihood of relapse. The efficacy of cannabinoid drugs in treating drug addiction, a disorder that still lacks effective therapeutic approaches, will be discussed.