文献知网节
  • 记笔记

Substances with analgesic activity among dermorphine analogues

Tatiana VoroninaLudmila GuzevatykhLudmila AndreevaTatiana EmelyanovaSergey SeredeninNikolay Myasoedov.Nikolay Myasoedov

State Zakusov Institute of Pharmacology RAMS.Institute of Molecular Genetics RAS.

摘要:<正> The synthesis and study of the structure - activity relationship were carried out in 43 fragments and analogues of dermorphine (aDM) by consecutive replacement individual amino acids residues. The optimal structures for analgesic,thermoregulatory and vasomotor activities were determined. Based on these findings new aDM were purposefully synthetised. including those stereochemically modified Pro in the 6 - th position. The aDM demonstrated a high analgesic activity (used tests as follows: tail flick; acetic acid caused writhing,hot plate,mechanical pressure of the tail,formaline test) The aDM caused no negative influence upon breath,exhibited alow narcogenic potential,and wide safety range.
会议名称:

第十五届国际药理学大会

会议时间:

2006-07

会议地点:

中国北京

  • 专辑:

    医药卫生科技

  • 专题:

    药学

  • 分类号:

    R96

  • 手机阅读
    即刻使用手机阅读
    第一步

    扫描二维码下载

    "移动知网-全球学术快报"客户端

    第二步

    打开“全球学术快报”

    点击首页左上角的扫描图标

    第三步

    扫描二维码

    手机同步阅读本篇文献

  • CAJ下载
  • PDF下载

下载手机APP用APP扫此码同步阅读该篇文章

下载:2 页码:75 页数:1 大小:33k

引文网络
  • 参考文献
  • 引证文献
  • 共引文献
  • 同被引文献
  • 二级参考文献
  • 二级引证文献
  • 批量下载
相关推荐
  • 相似文献
  • 读者推荐
  • 相关基金文献
  • 相关法规
  • 关联作者
  • 相关视频