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Role of microRNAs in ginsenoside-Rg1-induced angiogenesis

Patrick Y.K.YueN.K.MakRicky N.S.Wong

Department of Biology,Hong Kong Baptist University

摘要:<正>MicroRNAs(miRNAs)are small noncoding RNAs of 19-24 nucleotides.They regulate gene expression by translational repression or mRNA degradation in a sequence-specific manner; and are thereby implicated to regulate a variety of biological processes including cell proliferation, differentiation and apoptosis.Previously,ginsenoside-Rg1,a pharmacologically active component of Panax ginseng,has been found to promote angiogenesis and wound healing in vitro and in vivo. Since angiogenesis is crucial for a variety of physiological and pathological processes such as wound healing and tumorigenesis;in this study,we used human umbilical vein endothelial cells (HUVECs)as a cellular system to investigate the role of miRNA in Rg1-induced angiogenesis.By performing miRNA microarray,the expressions of 1812 miRNA in normal and Rg1-induced HUVECs were detected.Among them,17 down-regulated miRNAs(e.g.hsa-miR-377,has-miR214 and hsa-miR-23a)and 5 up-regulated miRNAs(e.g.hsa-miR-520h and hsa-miR-197)were found to be related to the Rg1-induced angiogenesis.Subsequently,the miRNA/target gene pairs were identified by the computational analysis;and they will be further validated by the gain-of function and loss-of function experiments.We believe that this specific miRNA signature can help us to explain the pharmacogenomic actions of Rg1 by acting as an angiogenic agent.
会议名称:

2008 International Conference on Ginseng

会议时间:

2008-09

会议地点:

中国吉林长春

  • 专辑:

    医药卫生科技

  • 专题:

    中药学

  • 分类号:

    R285

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