文献知网节

Brain opioid receptor responses to psychological stress in atopic dermatitis model mice,NC/Nga

Hiroo Amano1Chikako Kishi1Masahito Yasuda1Akiyama Hiroshi2Osamu Ishikawa1

1. Department of Dermatology,Gunma University Graduate School of Medicine2. National Institute of Health Sciences,Division of Novel Foods and Immunochemistry

摘要:<正>Background Atopic dermatitis is a common pruritic inflammatory skin disease.It has been well recognized that environmental factors such as mites and dusts and psychological stress exacerbate atopic dermatitis.Recently,we have demonstrated that psychological stress by itself can induce scratching behaviour and trigger atopic dermatitis-like skin changes in atopic dermatitis model mice,NC/Nga.Additionally,we have shown that the pretreatment with corticotropin-releasing factor(CRF)inhibits scratching behaviour induced by psychological stress.In this study,to explore the mechanism how psychological stress can induce itch and also how CRF inhibits scratching behaviour induced by psychological stress,we investigated the expression level of opioid receptors(u and k)mRNA in brain as well as other parameters. Methods and Results Under SPF condition,psychological stress elicited atopic dermatitis-like skin lesions along with the increased level of serum IgE in NC/Nga mice.Both u-opioid receptor antagonist and CRF suppressed scratching behaviour.Psychological stress decreased the mRNA expression of K-opioid receptors in brain,and pretreatment with CRF restored the mRNA levels of K-opioid receptors to those of control mice.On the other hand,psychological stress increased the mRNA expression of u-opioid receptors in brain,and pretreatment with CRF restored the mRNA levels of u-opioid receptors to those of control mice. Conclusion Our data indicate that CRF may suppress stress-induced scratching behaviour via through the restoration of altered expression of u and K-opioid receptors in brain.
会议名称:

The Second Eastern Asia Dermatology Congress(EADC2012)

会议时间:

2012-06-13

会议地点:

中国北京

  • 专辑:

    医药卫生科技

  • 专题:

    皮肤病与性病

  • 分类号:

    R758.2

  • 手机阅读
    即刻使用手机阅读
    第一步

    扫描二维码下载

    "移动知网-全球学术快报"客户端

    第二步

    打开“全球学术快报”

    点击首页左上角的扫描图标

    第三步

    扫描二维码

    手机同步阅读本篇文献

  • CAJ下载
  • PDF下载

下载手机APP用APP扫此码同步阅读该篇文章

温馨提示:阅读CAJ格式原文,请使用CAJ浏览器

下载:3 页码:235 页数:1 大小:37k

引文网络
  • 参考文献
  • 引证文献
  • 共引文献
  • 同被引文献
  • 二级参考文献
  • 二级引证文献
  • 批量下载
相关推荐
  • 相似文献
  • 读者推荐
  • 相关基金文献
  • 相关法规
  • 关联作者
  • 相关视频