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摘要:Background:Structural studies have reported anorexia nervosa(AN) patients with abnormal gray matter in several brain regions and dysfunctionality in some connected neural circuits.However,the role of white matter(WM) in AN patients has rarely been investigated.The present study aimed to assess alterations in WM microstructure in the whole brain of women with AN using a voxelbased method on diffusion tensor imaging(DTI) data.Method:The study enrolled eight female patients with AN and fourteen age-matched women as control(CW).The DTI data was collected for each subject to calculate the fractional anisotropy(FA) maps of the whole brain by the DTI-Studio software.Subsequently,a two-sample t-test(P<0.05,corrected) was performed to detect the difference in FA maps of AN and CW group,and a Pearson’ s correlation analyzed the relationship between mean FA value of brain regions and body mass index(BMI).Results:Compared to CW,AN patients displayed a significant decrease of FA maps in the left superior frontal gyrus(SFG),medial frontal gyrus(medFG),anterior cingulate cortex(ACC),middle frontal gyrus(MFG),inferior frontal gyrus(IFG),thalamus,and bilateral insula.Moreover,significantly positive correlations were established between the mean FA value of the left IFG,insula as well as thalamus and BMI in AN patients.Discussion:Our findings supported the presence of white matter pathology in patients with AN.The significant differences of FA maps,in patients with AN,are associated with their aberrant BMI.The results further improve our understanding of the pathophysiological mechanism underlying AN.
会议名称:

第二届之江国际精神医学论坛暨2016浙江省医学会精神病学分会学术年会暨浙江省医师协会精神科医师分会第九届年会

会议时间:

2016-11-10

会议地点:

中国浙江绍兴

  • 专辑:

    医药卫生

  • 专题:

    精神病学

  • 分类号:

    R749.7

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