Altered microstructure of brain white matter in women with anorexia nervosa:A diffusion tensor imaging（DTI） study
Shao-hua Hu1,2Hong Feng3Ting-ting Xu4Hao-rong Zhang5Zhi-yong Zhao5Jian-bo Hu1,2Hong-li Qi1,2Chan-chan Hu1,2Peng Zhang4Jian-bo Lai6Qiao-qiao Lu6Man-li Huang1,2Wei-juan Xu1,2Ning Wei1,2Ting-ting Mou1,2Shao-jia Lu1,2Jing Lu1,2Wei-hua Zhou1,2Yi Xu1,2Dong-rong Xu7
1. Department of Mental Health,First Affiliated Hospital,Zhejiang University School of Medicine2. The Key Laboratory of Mental Disorder's Management of Zhejiang Province3. Shaoxing No.Seven People's Hospital4. The Center of Mental Health,Xiaoshan Hospital5. Shanghai Key Laboratory of Magnetic Resonance,Key Laboratory of Brain Function Genomics,East China Normal University6. Zhejiang University School of Medicine7. Epidemiology Division & MRI Unit,Department of Psychiatry,Columbia University & New York State Psychiatric Institute
摘要：Background:Structural studies have reported anorexia nervosa（AN） patients with abnormal gray matter in several brain regions and dysfunctionality in some connected neural circuits.However,the role of white matter（WM） in AN patients has rarely been investigated.The present study aimed to assess alterations in WM microstructure in the whole brain of women with AN using a voxelbased method on diffusion tensor imaging（DTI） data.Method:The study enrolled eight female patients with AN and fourteen age-matched women as control（CW）.The DTI data was collected for each subject to calculate the fractional anisotropy（FA） maps of the whole brain by the DTI-Studio software.Subsequently,a two-sample t-test（P<0.05,corrected） was performed to detect the difference in FA maps of AN and CW group,and a Pearson’ s correlation analyzed the relationship between mean FA value of brain regions and body mass index（BMI）.Results:Compared to CW,AN patients displayed a significant decrease of FA maps in the left superior frontal gyrus（SFG）,medial frontal gyrus（medFG）,anterior cingulate cortex（ACC）,middle frontal gyrus（MFG）,inferior frontal gyrus（IFG）,thalamus,and bilateral insula.Moreover,significantly positive correlations were established between the mean FA value of the left IFG,insula as well as thalamus and BMI in AN patients.Discussion:Our findings supported the presence of white matter pathology in patients with AN.The significant differences of FA maps,in patients with AN,are associated with their aberrant BMI.The results further improve our understanding of the pathophysiological mechanism underlying AN.