Dendritic cell production of the chemokine CCL17 is required for optimal Th2 induction against both helminths and allergens
Peter Cook1Alexander Phythian-Adams1Sheila Brown1Freya Svedberg1Danen Cunoosamy2Irmgard Forster3Andrew MacDonald1
1. University of Manchester2. Astra Zeneka R&D Sweden3. University of Bonn
摘要：＜正＞Dendritic cells（DCs）are essential for initiation of type-2 responses,which are important for immunity to helminth infection as well as being a major contributor to allergic disease.However,the mechanisms DCs employ to promote type-2 responses remain poorly understood.We previously identified a crucial role for Mbd2,a methyl-Cp G binding protein that links DNA methylation to repressive chromatin structure,in regulating DC gene expression and ability to initiate Th2 immunity in
会议名称：
The 14th International Symposium on Dendritic Cells
会议时间：
2016-10-14
会议地点：
中国上海
- 专辑：
医药卫生科技
- 专题：
基础医学
- 分类号：
R392
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