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Dendritic cell production of the chemokine CCL17 is required for optimal Th2 induction against both helminths and allergens

Peter Cook1Alexander Phythian-Adams1Sheila Brown1Freya Svedberg1Danen Cunoosamy2Irmgard Forster3Andrew MacDonald1

1. University of Manchester2. Astra Zeneka R&D Sweden3. University of Bonn

摘要:<正>Dendritic cells(DCs)are essential for initiation of type-2 responses,which are important for immunity to helminth infection as well as being a major contributor to allergic disease.However,the mechanisms DCs employ to promote type-2 responses remain poorly understood.We previously identified a crucial role for Mbd2,a methyl-Cp G binding protein that links DNA methylation to repressive chromatin structure,in regulating DC gene expression and ability to initiate Th2 immunity in
会议名称:

The 14th International Symposium on Dendritic Cells

会议时间:

2016-10-14

会议地点:

中国上海

  • 专辑:

    医药卫生科技

  • 专题:

    基础医学

  • 分类号:

    R392

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