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Folic Acid-Polyethyleneimine-Ethosome as a Potential Tumor Targeting Carrier: Preparation, Characterization and in vitro Evaluation

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【作者】 宋新然马琳琳GOMAA Elfawal洪火炎梁经天孙美琪张林王红声

【Author】 SONG Xinran;MA Linlin;GOMAA Elfawal;HONG Huoyan;LIANG Jingtian;SUN Meiqi;ZHANG Lin;WANG Hongsheng;Key Laboratory of Science & Technology of Eco-Textile,Ministry of Education;College of Chemistry,Chemical Engineering and Biotechnology,Donghua University;Advanced Technology and New Materials Research Institute, City of Scientific Research and Technological Applications;Department of Pharmacy,Shaoxing People’s Hospital,Shaoxing Hospital of Zhejiang University;

【通讯作者】 张林;王红声;

【机构】 Key Laboratory of Science & Technology of Eco-Textile,Ministry of EducationCollege of Chemistry,Chemical Engineering and Biotechnology,Donghua UniversityAdvanced Technology and New Materials Research Institute, City of Scientific Research and Technological ApplicationsDepartment of Pharmacy,Shaoxing People’s Hospital,Shaoxing Hospital of Zhejiang University

【摘要】 A novel composite carrier of folic acid( FA)-polyethyleneimine( PEI)-ethosome( Eth)( FA-PEI-Eth)was developed for the treatment of cancers through loading and targeting delivery of multidrug( including gene and other drugs) into cancer cells. Physical and chemical property tests were done to prove the grafting of the composite. Gel retardation test was done to determine the optimal ratio of DNA@ PEI complex,and cytocompatibility tests and tumor cell uptake tests were done to evaluate the efficiency of the composite. The results demonstrated that the FA-PEI-Eth could effectively deliver a gene and other drugs into tumor cells simultaneously,and suggested that this composite would be a promising carrier in tumortargeted therapy applications.

【基金】 Shanghai Science and Technology Committee Project,China(No.18490740400);Open Foundation of Key Laboratory of Science&Technology of Eco-Textile,China(No.Eco-KF-201612);Opening Project of Zhejiang Provincial Preponderant and Characteristic Subject of Key University,Zhejiang Chinese Medical University,China(No.ZYAOX2018035);Project of Health and Family Planning Commission of Zhejiang Province,China(No.2018KY831)
  • 【分类号】TQ460.4
  • 【下载频次】1
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