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Effects of Triptolide on Inflammatory Factors in Alzheimer’s Disease Cell Model

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【Author】 WANG Hui-ling1,ZHANG Xiao-hong1,ZHOU Xiao-chun1,WANG Bing2,WANG Xiao-min31.Chengde Medical College,Chengde,Hebei 067000,China;2.Affiliated Hospital of Chengde Medical College,Chengde,Hebei 067000,China;3.Capital Medical University,Beijing 100069,China

【摘要】 [Objective]To observe the preventive and therapeutic effects of T10 on A β1-42 oligomer mediated Alzheimer’s Disease(AD) and its mechanism.[Method]The microglia cells were pre-treated with 10-11-10-8 mol/L T10 for 12 h before 10 μmol/L A β1-42 was added in,and incubated for 12 hours together.The content of TNF-α and IL-1β in supernatant were determined by ELISA.The conditioned medium was collected and was added with the hippocampus neurons treating for 24 hours.The survival rate of the neurons was detected by MTT.[Result]T10 could significantly decrease the release of TNF-and IL-1β induced by A β1-42 from microglia in vitro and raise the survival rate of the hippocampus neurons.[Conclusion]T10 could protect the hippocampus neurons through inhibiting the activation of microglia.

【基金】 Supported by Hebei Province Key Project Program of Medical Sciences Research(20090581)
  • 【分类号】R749.16
  • 【被引频次】3
  • 【下载频次】12
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