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Study on Bioassay-guided Isolation of Cytotoxic Compounds from Bark of Betula albo-sinensis Burk

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【Author】 FANG Yu-chun,ZHAO Ming-liang,LUO Yan School of Medicine and Pharmacy,Ocean University of China,Qingdao,Shandong 266003,China

【摘要】 [Objective]To study the anti-tumor active ingredients of Betula albo-sinensis Burk.bark.[Method]The compounds were isolated and purified by bioassay-guided procedure using various chromatographic methods and the structures were identified by modern spectroscopic technology.[Result]Five pentacyclic triterpenoids were obtained from the active substances of chloroform extract and identified as lup-20(29)-en-28-ol-3β-yl caffeate(Ⅰ),betulin(Ⅱ),lupeol(Ⅲ),betulinic acid(Ⅳ) and betulonic acid(Ⅴ).All the compounds showed cytotoxic activities on Bel-7402,B16 and A549 cell lines.[Conclusion]All the compounds obtained from this study were isolated from Betula albo-sinensis Burk.firstly.

  • 【分类号】R284
  • 【被引频次】2
  • 【下载频次】21
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