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Study on Immunoregulation Effects of Different Extracts from RADIX ASTRAGALI and RADIX HEDYSARI

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【Author】 YU Li1,CAO Yi2,WEI Xiao1,XU Li1,FANG Tai-hui1* 1.Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica,Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210029,China;2.Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210046,China

【摘要】 [Objective] The research aimed to comparatively study the immunoregulation effects of different extracts from RADIX ASTRAGALI and RADIX HEDYSARI using macrophages as target cells.[Method] Lipopolysaccharide(LPS) and dexamethasone(DEX) were used to treat cells as stimulant and immunodepressant,respectively.Taking NO as index reflecting functional changes of macrophages,effects of RADIX ASTRAGALI and RADIX HEDYSARI extracts with different concentration on NO secretion of macrophages under 3 states including activated,suppressed and normal were compared.[Results] Water extracts from RADIX ASTRAGALI and RADIX HEDYSARI could intensify either the normal cells function or those cells treated with 10 ng/ml LPS,and the former was better.Ethanol extracts of the two were provided with little effects on macrophages under suppressed state,but water extracts from residues of ethanol extracts could also activate the function of macrophages.[Conclusion] The active components that could activate macrophages were contained in water extracts from RADIX ASTRAGALI and RADIX HEDYSARI,of which the former effect was more obvious.

【基金】 Supported by the Natural Science Basic Research Foundation of the Higher Education Institutions of Jiangsu Province (Grant No. :07KJB360086);the National Natural Science Foundation of China (Grant No. :30901999)
  • 【分类号】R285
  • 【被引频次】3
  • 【下载频次】28
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