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Effects of Total Saponins from Ranunculus japonicus on Hypoxia Tolerance and Memory Ability of Mice

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【Author】 QIN Ru-lan*, MENG Qing-shuang Department of Pharmaceutics and Food Science, Tonghua Normal University, Tonghua, Jilin 134001, China

【摘要】 [Objective] The aim was to observe the effects of total saponins from Ranunculus japonicus Thunb. on hypoxia tolerance and memory ability of mice. [Method] Mice were given with different doses of total saponins from Ranunculus japonicus Thunb. by gastric perfusion for successive 14 days. Then, the hypoxia tolerance time and successful times of mice to run a maze were calculated, respectively. [Result] Mice treated with low-dose and high-dose total saponins from Ranunculus japonicus Thunb. could significantly prolong anti-hypoxia time and improve memory ability. [Conclusion] The total saponins from Ranunculus japonicus Thunb. could significantly promote intelligence development and prolong life of mice. Thus, total saponin is of high medical value and has good development prospect.

  • 【分类号】S567.53;S865.13
  • 【被引频次】3
  • 【下载频次】17
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