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Preparation and Content Determination of Compound Scrophulariae Troches

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【Author】 FENG Suo-min1* ,WANG Yun2,GAO Wen-qing1,QING Li-yuan1,XUE Peng-chao1,SUN Wen-ji3 1. Department of Pharmacy,Xi’an Medical University,Xi’an,Shaanxi 710021,China; 2. Out-patients Department of Xi’an Army College,Xi’an, Shaanxi 710108,China; 3. Shaanxi Key Laboratory of Biomedicine,Northwest University,Xi’an,Shaanxi 710069,China

【摘要】 [Objective]To prepare compound scrophulariae troches and determine the content of its main active constituents. [Method]Taking the taste,appearance characteristics and disintegrating time as index,the prescription and preparation process of troches with the extracts from the aerial parts of Scrophularia ningpoensis Hemsl. as primary drug were confirmed through wet granulation tabletting method. Using the harpagoside as an index,HPLC method was adopted to establish a quality control standard for compound scrophulariae troches. [Result]The optimum prescription composed of 6.7% extracts from the aerial parts of S. ningpoensis,4% E. ulmoides leaf extract,36. 7% mixture of mannitol and sugar ( V/V, 1∶1) ,0. 95% menthol crystal and 0. 24% magnesium stearate. [Conclusion] In accordance with the selection of prescription and preparation, troches that conformed to the requirements were prepared,and the content of its main active ingredients were determined.

【基金】 Supported by the Visiting Scholars Program of Department of Education of Shaanxi Province (09JS084)
  • 【分类号】R286
  • 【下载频次】25
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