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Research on the Effect of FRUCTUS GARDENIAE Extract on Reducing Uric Acid in Hyperuricemia Mice and Its Action Mechanism

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【Author】 ZHU Ji-xiao,ZHU Yu-ye,LUO Guang-ming,ZENG Jin-xiang*,SHI Jing-jing,XU Yun-feng,WANG Xiao-yun,WU Bo The Chinese Medicine Germplasm Resource Engineering Technology Research Center of Jiangxi Province,Jiangxi University of Traditional Chinese Medicine,Nanchang,Jiangxi 330004,China

【摘要】 [Objective] To study the effect of FRUCTUS GARDENIAE extract on the level of uric acid in hyperuricemia mice and investigate the mechanism.[Method] After intragastric administration of FRUCTUS GARDENIAE extract at different doses,the level of uric acid and the activity of xanthine oxidase(XOD) in hyperuricemia mice induced by potassium oxonate were respectively observed.[Result] Different doses of FRUCTUS GARDENIAE extract could obviously reduce the level of serum uric acid and inhibit the activity of XOD in hyperuricemia mice.However,extract had no significant effect on the level of serum uric acid in normal mice.[Conclusion] FRUCTUS GARDENIAE extract could significantly reduce the level of serum uric acid in hyperuricemia mice,which is related to its inhibitory effect on XOD.

【基金】 Supported by the National "Twelfth-Fiver-Year" Key Technology R&D Program (2011BAI04B01)
  • 【分类号】R285.5
  • 【被引频次】1
  • 【下载频次】37
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