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Research on Preparation Process of Dropping Pills from Pueraria lobata(Willd.) Ohwi Bud and Content Determination of Puerarin

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【Author】 YAN Xian-hai1*,ZHANG Ai-li1,TIAN You-qing1,2 1.Lianyungang TCM Branch,Jiangsu Union Technical Institute,Lianyungang,Jiangsu 222007,China;2.New Drug Screening Center,China Pharmaceutical University,Nanjing,Jiangsu 210009,China

【摘要】 [Objective] To optimize the preparation process of dropping pills from Pueraria lobata(Willd.)Ohwi bud and determine the content of puerarin.[Method] Taking the percent rate of roundness,weight difference rate and dissolving time duration of dropping pills as indexes,the PEG6000-S-40 ratio,matrix-drug ratio,refrigerant temperature and dropping rate were optimized by orthogonal test with table L9(34) in the course of preparing dropping pills from P.lobata bud.And the content of puerarin in dropping pills was determined by HPLC.[Result] The optimal conditions for preparing dropping pills from P.lobata bud were as follows:PEG6000-S-40 ratio 3:1(g/g),matrix-drug ratio 4:1(g/g),refrigerant temperature 35-40 ℃,dropping rate 50 drops/min.And the average content of puerarin in three batches of dropping pills were(52.26 ±1.33) mg/g.[Conclusion] The preparation process of dropping pills from P.lobata bud is reasonable and repetitive.The dropping pills have good quality of appearance and meet the requirements of China Pharmacopoeia.The HPLC method is advanced,accurate and reliable,which can be used to control the quality of dropping pills from P.lobata bud.

  • 【分类号】R286.0
  • 【被引频次】1
  • 【下载频次】71
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