节点文献

Effects of Polysaccharides from Potentilla anserine on the Levels of Cytokines in Tumor Mice

免费订阅

【Author】 CHENG Ying, SONG Jiu-hua, LIU Su-jun* Natural Products Utilization Research Unit, Leshan Normal College, Leshan, Sichuan 614004, China

【摘要】 [Objective] To study the effects of polysaccharides from Potentilla anserine (PAP) on the levels of interleukin-2 (IL-2) and tumor necrosis factor-α (TNF-α) from peripheral blood. [Method] The mice models with tumor S180 were established and treated with 50, 100 and 200 mg/kg PAP by gastric perfusion, respectively. The inhibition rate of S180 tumor was measured to investigate the antitumor activity in vivo of PAP. The levels of IL-2 and TNF-α in mice peripheral blood were determined with ELISA. [Result] The tumor inhibition rates were 46.41%, 52.29% and 59.48% in different groups treated with 50,100 and 200 mg/kg PAP in vivo, respectively. Of these, the inhibition rate of CY and low-dose PAP was equal to that of medium- and high-dose PAP, significantly higher than that of cyclophosphamide. Three dose groups of PAP could significantly increase the content of IL-2 and TNF-α spleen index. [Conclusion] The compound PAP could improve the antitumor activity and immunological function of S180 tumor-bearing mice.

【基金】 Supported by the National Science and Technology Support Project (2007BAC18B04);Key Project of Ministry of Education of Sichuan Province (08ZA095)
  • 【分类号】R285.5
  • 【被引频次】1
  • 【下载频次】14
节点文献中: 

本文链接的文献网络图示:

浏览历史:
下载历史: