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Proliferation Inhibition and Induced Differentiation Effects of Carthamin on Leukemic Cells

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【Author】 WU Zhi-yan1, JIA Yan-long2, ZHAO Fan-rong2, LI Peng2, YIN Ya-ling3* 1. The First Affiliated Hospital, Xinxiang Medical University, Xinxiang, Henan 453003, China; 2. College of Pharmacy, Xinxiang Medical University, Xinxiang, Henan 453003, China; 3. School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan 453003, China

【摘要】 [Objective] To research the proliferation inhibition and induced differentiation effects of carthamin on K562 leukemic cells. [Method] With the cultured K562 leukemic cells as the research materials, the proliferation inhibition and induced differentiation effects of carthamin were observed by the XTT test, colony formation test, hemoglobin benzidine staining test and morphological experiment. [Result] The activity and colony formation of leukemic cells were dose-dependently suppressed by carthamin (P<0.05); the hemoglobin benzidine staining test and morphological experiment also proved that the carthamin dose dependently induced the K562 leukemic cells to the hemoglobin end cells. [Conclusion] Carthamin had significant effects of proliferation inhibition and induced differentiation on K562 leukemic cells.

【基金】 Supported by the 2010 Natural Science Research Program of Henan Educational Committee(2010B320011)
  • 【分类号】R733.7
  • 【下载频次】6
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