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Effect of Two Chinese Herbal Compounds on the Protection of Gastric Mucosal Lesion in Rat and Its Blood Index

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【Author】 XU Xian-yun1,LI Hong-liang2,SUN Li-bo3,YUAN Shi-jie2,PAN Ming-qian1,FAN Xiao-na1 1.School of Basic Medical Sciences,Gannan Medical University,Ganzhou,Jiangxi 341000,China;2.School of Pharmacy,Gannan Medical University,Ganzhou,Jiangxi 341000,China;3.The Affiliated Hospital of Medical College of Qingdao University,Qingdao,Shandong 266001,China

【摘要】 [Objective] To observe the effects of two Chinese herbal compounds ( LWZY) on the protection of gastric mucosal lesion in rat and its blood index.[Method]Three models were set up including the gastric mucosal lesion caused by anhydrous alcohol,gastric mucosal lesion caused by aspirin and gastric mucosallesion caused by hydrochloric acid,and the medicine was intragastrically administrated,the indices of gastric mucosa damage index,prothrombin time ( PT) ,fibrinogen ( FIB) ,activate part blood coagulation time ( APTT) and thrombin time ( TT) were selected to evaluate the anti-gastric mucosal lesion performance of twoChinese herbal compounds and its impact on the blood index. [Result]Cimetidine and LWZY groups had significant protective effects on rats in model of gastricmucosal lesion by anhydrous alcohol,the model of gastric mucosal lesion by aspirin and the model of gastric mucosal lesion by hydrochloric acid,the gastric mucosadamage index of all treatment groups significantly reduced compared with that of model group ( P < 0. 05; P < 0. 01) ,the blood in the anhydrous alcohol model withLWZY reduced significantly in PT,FIB,APTT and TT compared to the normal group ( P < 0. 05; P < 0. 01) with a statistic significance; the blood in the hydrochloric acid model increased slightly in PT,FIB,APTT and TT than the normal group; PT and FIB of LWZY group significantly reduced compared with modelgroup,but without statistic significance,APTT and TT were reduced significantly( P < 0. 05; P < 0. 01) ,and had a statistic significance,the indices of blood PT,FIB,APTT and TT in aspirin model were obviously higher than that in the normal group,while the LWZY group was reduced significantly in PT,FIB,APTT andTT compared to model group ( P < 0. 05; P < 0. 01) ,and had statistic significance. [Conclusion]LWZY could significantly protect the rat gastric mucosa damagecaused by anhydrous alcohol,aspirin and hydrochloric acid,and promote blood clotting in vivo,the action mechanism might be related to the blood coagulation factor and hormone level.

【基金】 Supported by the Project of Jiangxi Province Education Department (No.GJJ11577)
  • 【分类号】S853.7
  • 【下载频次】8
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