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Study on the Stability of Ginsenoside Rg1 before and after PEG Modification

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【作者】 Mei LIULi WANGKaili HUJianfang FENG

【Author】 Mei LIU, Li WANG, Kaili HU, Jianfang FENG* Murad Research Center for TCM Modernization, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

【机构】 Murad Research Center for TCM Modernization,Shanghai University of Traditional Chinese Medicine

【摘要】 [Objective] To investigate the stability of ginsenoside Rg1 before and after PEG modification (PEG-Rg1) in isolated rat stomach. [Method] SD rats, after 18 h of fasting, were randomly divided into Rg1 group and PEG-Rg1 group. The stomach ex vitro of SD rats in Rg1 group and PEG-Rg1 group were respectively injected with Rg1 stomach perfusion fluid and PEG-Rg1 infusion fluid and then incubated at 37 ℃ under shaking conditions. Then the contents of ginsenoside Rg1 in samples, taken in different time points, were determined by UPLC to observe and compare the stability of ginsenoside Rg1 with PEG-Rg1 in the stomach ex vitro. [Result] Ginsenoside Rg1 in the rat stomach showed poor stability, the content of Rg1 was only 26.8% in 2 h, that is, 73.2% was degraded. PEG-Rg1 was improved in the rat stomach, 81.8% of PEG-Rg1 was still measured in 2 h, only degradation of 18.2%. [Conclusion] PEG-modified ginsenoside Rg1 can improve the stability of ginsenoside Rg1 in stomach.

【基金】 Supported by National Nature Science Foundation of China(30873445)
  • 【分类号】R284.1
  • 【被引频次】1
  • 【下载频次】22
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