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Effects of Flavonoids from Stem and Leaf of Scutellaria baicalensis Georgi on Memory Impairment and Expression of ChAT and NOS in Chronic Cerebral Ischemia Rats

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【作者】 Bowen QINYazhen SHANG

【Author】 Bowen QIN,Yazhen SHANG * Hebei Provincial Key Laboratory of Traditional Chinese Medicine Research and Development / Institute of Traditional Chinese Medicine,Chengde Medical College,Chengde,Hebei 067000,China

【机构】 Hebei Provincial Key Laboratory of Traditional Chinese Medicine Research and Development / Institute of Traditional Chinese Medicine,Chengde Medical College

【摘要】 [Objective]To investigate the effects of flavonoids from stem and leaf of Scutellaria baicalensis Georgi on memory impairment and expression of ChAT and NOS in chronic cerebral ischemia rats.[Methods]The model of chronic cerebral ischemia was established in female Sprague-Dawley (SD) rats by bilateral carotid artery occlusion for 2 months.By employing Morris water maze,expressions of chloine acetyl-transferase (ChAT) ,neuronal nitric oxide synthase (nNOS) ,inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS) were examined by immunohistochemical method to investigate the functions of learning and memory.[Results]Compared with the sham group,memory ability and the expressions of ChAT and eNOS,were significantly decreased,while the expressions of nNOS and iNOS were dramatically upregulated.However,the treatment of 17.5,35.0 and 70.0 mg/kg SSF for 38 d on ischemia rats showed significantly improved impairment of memory ability and the abnormal changes of ChAT,eNOS,nNOS and iNOS in the brain of ischemia rats.[Conclusion] Flavonoids from stem and leaf of Scutellaria baicalensis Georgi (SSF) can improve the memory impairment induced by chronic cerebral ischemia in rats,which may be related to regulate the abnormal changes of ChAT and NOS in the ischemic rat brains.

【基金】 Supported by Program from State Administration of Traditional Chinese Medicine (02-03-ZP18);Supporting Programs for 100 Distinguished Scholars at Universities in Hebei Province
  • 【分类号】R285.5
  • 【下载频次】23
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