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The Effects of Total Flavonoids of Lespedeza virgata on Chronic Renal Failure Rats

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【作者】 Zhiqin HUANGHongliang LIQilai CHENG

【Author】 Zhiqin HUANG * ,Hongliang LI,Qilai CHENG Pharmacy Department,Gannan Medical University,Ganzhou,Jiangxi 341000,China

【机构】 Pharmacy Department,Gannan Medical University

【摘要】 [Objective]To investigate the therapeutic function of Lespedeza virgata on chronic renal failure (CRF) rats and its effects on following indexes in rats: urine protein content,blood routine items,blood urea nitrogen (BUN) and serum creatinine (SCr).[Method]The tested animals were randomly divided into 4 groups: sham operation group,model group,group treated with low dose and group treated with high dose of total flavonoids of Lespedeza virgata.CRF rat models were constructed by removing 5/6 of the kidney and then treated with different dose of total flavonoids of Lespedeza virgata.After 35 and 70 days of treatment,the rat urine was collected and the urine protein content was determined; the rat blood was collected and the blood routine items were examined,the blood urea nitrogen and serum creatinine were tested; rats were sacrificed and the pathological and histomorphometric changes were observed,the pathological composite scores were evaluated.[Result]Treatment with low dose and high dose of total flavonoids of Lespedeza virgata decreased the urine protein content of chronic renal failure rats,but the difference is not statistically significant compared to model group; there is no obvious improvement of blood routine items in groups treated with low dose and high dose of total flavonoids of Lespedeza virgata; blood urea nitrogen (BUN) and serum creatinine (SCr) in CRF rats were reduced in groups treated with low dose and high dose of total flavonoids of Lespedeza virgata,the difference is statistically significant compared to model group (P<0.05); pathological and morphological examination shows that the pathological composite scores were obviously decreased in groups treated with low dose and high dose of total flavonoids of Lespedeza virgata,the difference is statistically significant compared to model group (P<0.05).[Conclusion]Lespedeza virgata has protective effects on the kidney of CRF rats,the mechanism of which is probably associated with an increase in renal blood flow,augmented glomerular filtration rate,promotion of metabolites excretion,reduction in the blood urea nitrogen and serum creatinine and other aspects.

【基金】 Supported by Natural Science Foundation Project of Jiangxi Province of China (jgNO:2007081);Educational Commission Project of Jiangxi Province of China (NO:2008107)
  • 【分类号】R285
  • 【被引频次】1
  • 【下载频次】27
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