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Preparation and Pharmacodynamic Assay of Tongnao Oral Solution

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【作者】 Luyang LUYuan LIUZhifeng ZHANG

【Author】 Luyang LU * ,Yuan LIU,Zhifeng ZHANG Ethnic Medicine Institute,Southwest University for Nationalities,No. 16,South 4 th Section,1 st Ring Road,Chengdu,Sichuan 610041,China

【机构】 Ethnic Medicine Institute,Southwest University for Nationalities

【摘要】 [Objective]To solve the severe precipitation of Tongnao oral solution and evaluate its pharmacodynamic effects.[Methods]The main components of Tongnao oral solution,including Red Ginseng,Notoginseng,Chuanxiong,Rhubarb and Leech,were extracted respectively for pair combination testing. Clotting time of normal mice and ischemic mice was employed as the indicator for evaluating the pharmacodynamics of final products.[Results]The pair combination testing showed that tannin in rhubarb would act on some components of other medicinal herbs and produce precipitation. After tannin was removed by using improved gelatin method,the Tongnao oral solution was clear and stable, and it could remarkably elongate the clotting time of normal mice and ischemic mice.[Conclusion]This technique can well solve the severe precipitation of Tongnao oral solution and ensure the effectiveness of the products.

【基金】 Supported by Key Projects in the China Ministry of Science and Technology (Pillar Program No.2012BAI27B07);Supported by the Fundamental Research Funds for the Central Universities,Southwest University for Nationalities (12NZYQN14)
  • 【分类号】R286
  • 【下载频次】7
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