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Regulating Effects of Dragon’s Blood on the Lung Injury Repair of Rats and Its Mechanism

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【作者】 Liteng YANGXin LIUDeyun CHENGXun FANGMao MUXiaobo HULi NIE

【Author】 Liteng YANG;Xin LIU;Deyun CHENG;Xun FANG;Mao MU;Xiaobo HU;Li NIE;Department of Respiratory Medicine,Hospital of Integrated Traditional Chinese Medicine and Western Medicine,Southern Medical University;Zunyi Medical and Pharmaceutical College;Department of Respiratory Medicine,West China Hospital,Sichuan University;

【机构】 Department of Respiratory Medicine,Hospital of Integrated Traditional Chinese Medicine and Western Medicine,Southern Medical UniversityZunyi Medical and Pharmaceutical CollegeDepartment of Respiratory Medicine,West China Hospital,Sichuan University

【摘要】 [Objective]To research the regulating effects of dragon’s blood on the lung injury repair of rats and its mechanism.[Methods]Lung injury repair model of rats was established by dripping the bleomycin into trachea.Rats were given the dragon’s blood by gavage during the process of lung injury repair.Lung tissues of rats were collected on the 14thand 28thdays.Tissue chip was adopted;HE and collagen staining and immunohistochemical analysis were carried out.The collagen,collagen I and inflammatory cells were quantitatively analyzed.The TGFβ1mRNA expression of lung tissue was researched by Real-Time Fluorescence Quantitative RT-PCR.[Results]Dragon’s blood had significant inhibitory effects on the inflammatory degrees of lung tissues and the collagen overdeposition on the two days(P<0.05);IOD values reduced from(0.549 2±0.210 5)and(0.957 8±0.375 6)to(0.274 9±0.159 2)and(0.318 1±0.121 0),respectively.Dragon’s blood significantly reduced the TGFβ1mRNA expression on the two days(P<0.05);and the IOD values decreased from(0.021 9±0.011 0)and(0.017 0±0.015 7)to(0.008 3±0.002 4)and(0.006 2±0.005 1),respectively.[Conclusions]Dragon’s blood could restrict the inflammatory injury of lung tissues,promote its repairing,and regulate the excessive repairing of mesenchyme through inhibiting the overdeposition of collagen,especially collagen I.The changes of collagen and collagen Imight be related to the expression decrease of TGFβ1mRNA in lung tissues.

  • 【分类号】R285.5
  • 【下载频次】37
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