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The Apoptosis of Human Tongue Carcinoma Induced by Plumbago zeylaniea L. and Exploration of Its Mechanism of Action

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【作者】 Zexiang DUFarui BAI

【Author】 Zexiang DU;Farui BAI;Guilin Medical University;Medical Department 75223 Troop in Guangzhou Military Region;

【机构】 Guilin Medical UniversityMedical Department 75223 Troop in Guangzhou Military Region

【摘要】 [Objective]To discuss the apoptosis of human tongue carcinoma induced by Plumbago zeylaniea L. and the impact of P. zeylaniea on telomerase activity. [Methods] The apoptosis of human tongue SqCa cultured in vitro was induced by the petroleum ether extracts from P. zeylaniea and then detected by flow cytometry. With Tca-8113 ad target cell,the in situ TRAP method was adopted to determine the telomerase activity. [Results] The apoptosis of SqCa Tca-8113 increased obviously when induced by the 8 mg / mL petroleum extracts from P. zeylaniea for 24 and 48 h; after 72 h,the telomerase activity declined significantly,and the inhibitive effect of telomerase activity increased with the concentration of P. zeylaniea concentration,showing a dose-dependent manner. [Conclusions] The petroleum ether extracts from Plumbago zeylaniea L. showed significant inhibitive effect on the proliferation of SqCa Tca-8113; and there is a possibility that P. zeylaniea fights against cancer by inhibiting telomerase activity and inducing SqCa apoptosis.

  • 【分类号】Q255
  • 【下载频次】9
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