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Antifebrile Effect of Bupleurum Injection on LPS-induced Fever Model Rats

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【作者】 Yang GAOZhibin WANGZeping ZUOYuchi HUChunran CAOYudong GUOBisong WANG

【Author】 Yang GAO;Zhibin WANG;Zeping ZUO;Yuchi HU;Chunran CAO;Yudong GUO;Bisong WANG;Beijing Institute for Drug Control;

【机构】 Beijing Institute for Drug Control

【摘要】 [Objective]To study antifebrile effect of bupleurum injection on male SD model rats with LPS-induced fever. [Methods]Febrile rats model was modeled by intraperitoneal injection of LPS( 100 μg / kg). We injected rats with bupleurum injection of different concentrations,5. 00,2. 50 and 1. 25 mL / kg,respectively. Body temperatures of rats in each group were recorded at 0. 5,1. 0,1. 5,2. 0,2. 5,3. 0, 3. 5,4. 0,4. 5,5. 0,5. 5,6. 0,6. 5,7. 0 and 8. 0 h. With the data,we made a drawing of average heating curves and explored effects of bupleurum injection on body temperatures of febrile model rats. [Results] After intraperitoneal injection of LPS( 100 μg / kg),rats in model group showed obvious three-phrase heat. 4 hours after building the model,peak value( 1. 69 ℃) of body temperature rise appeared. Intramuscular injection of bupleurum injection( 5. 00,2. 50 and 1. 25 mL / kg) could significantly lower body temperatures of above-mentioned febrile model rats and it’s lasted for 7 to 8 hours. The average values of temperature rise at various time points revealed that antifebrile effect of bupleurum injection had a good dose-dependence. [Conclusions]Bupleurum injection had strong antifebrile effect on LPS-induced febrile model rats and the antifebrile effect had a good dose-dependence.

  • 【分类号】S567.23
  • 【被引频次】1
  • 【下载频次】29
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